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Updated: May 6, 2026

Profiling Individual Human Embryonic Stem Cells by Quantitative RT-PCR
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Published on: May 29, 2014

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Quantifying human pluripotent stem cell attributes with population balance modeling.

Aedan Brown1, Demetrios M Stoukides1, Emmanuel S Tzanakakis2,3,4,5

  • 1Department of Chemical and Biological Engineering, Tufts University, Medford, MA, 02155, USA.

Stem Cell Research & Therapy
|October 15, 2025
PubMed
Summary

This study introduces a new method to derive physiological state functions (PSFs) for human stem cells, moving beyond population averages. This advancement is crucial for understanding stem cell heterogeneity and improving the biomanufacturing of stem cell therapeutics.

Keywords:
BioprocessingHuman pluripotent stem cellsOCT4Population balance equation modelsSingle-cell physiological state functions

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