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Investigating IgG Levels in Pediatrics with Kawasaki Disease and Its Association with Clinical Outcomes: A

Seyed Mehdi Aghapour1, Mousa Ghelichi-Ghojogh2, Jabbar Parhiz3

  • 1Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Medical Journal of the Islamic Republic of Iran
|October 15, 2025
PubMed

Insights

This study investigated IgG levels in Kawasaki Disease patients, finding no significant difference between sexes. Early diagnosis and treatment, including intravenous immunoglobulin (IVIG), are crucial for preventing complications in children with this vasculitis.

Area of Science:

  • Pediatrics
  • Immunology
  • Rheumatology

Background:

  • Kawasaki Disease is a critical pediatric systemic vasculitis requiring prompt aspirin and IVIG treatment.
  • Early intervention is key to preventing severe complications such as coronary artery aneurysms.

Purpose of the Study:

  • To examine IgG levels in pediatric patients diagnosed with Kawasaki Disease.
  • To explore the correlation between IgG levels and clinical outcomes in Kawasaki Disease patients.
  • To analyze demographic and clinical characteristics of Kawasaki Disease patients.

Main Methods:

  • A cross-sectional study involving 36 pediatric patients with Kawasaki Disease at Taleghani Hospital.
  • Patients were classified as complete or incomplete Kawasaki Disease.
  • Data collected included IgG levels, clinical features, laboratory results, and echocardiograms; analyzed using t-tests and Chi-square tests.

Main Results:

  • The majority of patients (63.9%) were aged 1-5 years; 89.2% showed no coronary involvement.
  • A high response rate to treatment (91.7%) was observed.
  • Elevated inflammatory markers (ESR, CRP) were common (72.2%); IgG levels were slightly higher in females but not significantly.

Conclusions:

  • Prompt diagnosis and treatment, including IVIG, are vital for managing Kawasaki Disease and preventing complications.
  • Paraclinical findings, including IgG levels, are important indicators for treatment response and patient outcomes.
Abstract

Keywords:
IgG levelKawasaki diseasePediatric

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