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Updated: Jan 15, 2026

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging

Published on: April 27, 2014

Effectiveness of Transcranial Direct Current Stimulation on Cognitive Function: A Pilot Study.

Mehrnaz Afsharipoor¹, Mahnaz Hejazi-Shirmard², Minoo Kalantari¹

¹Department of Occupational Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Medical Journal of the Islamic Republic of Iran

|October 15, 2025

Summary

This summary is machine-generated.

Combining occupational therapy with transcranial direct current stimulation (tDCS) significantly improved cognitive functions like working memory and planning in traumatic brain injury (TBI) patients. This suggests tDCS is a valuable complementary treatment for TBI rehabilitation.

Keywords:

Cognition Transcranial Direct Current Stimulation Traumatic Brain Injury

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Area of Science:

Neuroscience
Rehabilitation Medicine
Cognitive Psychology

Background:

Traumatic brain injury (TBI) frequently causes cognitive impairment, impacting daily life.
Occupational therapy is a standard rehabilitation approach for TBI.
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique.

Purpose of the Study:

To evaluate the combined effects of occupational therapy and tDCS on cognitive function in TBI patients.
To determine if tDCS enhances the benefits of occupational therapy for TBI cognitive rehabilitation.

Main Methods:

A semi-experimental study involving 24 moderate to severe TBI patients.
Random assignment to either occupational therapy alone (control) or occupational therapy with tDCS (experimental).
10 daily sessions of occupational therapy, with the experimental group receiving 20 minutes of tDCS during sessions. Cognitive functions assessed using WCST, Tower of London, N-back, and Stroop tests.

Main Results:

Both groups showed improvements in executive functions post-intervention.
The experimental group demonstrated significant enhancements in working memory (p=0.002), planning (p=0.002), and problem-solving (p=0.001).
No significant difference was found in selective attention between the groups (p=0.310).

Conclusions:

Combining occupational therapy with tDCS significantly improves specific executive functions in TBI patients.
tDCS serves as an effective complementary treatment for enhancing cognitive rehabilitation in TBI.
Further research may explore tDCS's role in other aspects of TBI recovery.