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Management of Arrhythmic Mitral Valve Prolapse: Potential Impact and Current Evidence
Serghei Covantsev1, Andia Taghdiri2, Anna Bumbu1
1Department of Clinical Research and Development, Botkin Hospital, 125284 Moscow, Russia.
Reviews in Cardiovascular Medicine
|October 15, 2025
Summary
Mitral valve prolapse (MVP) affects 2-3% of people and can lead to mitral regurgitation. While often benign, MVP is linked to sudden cardiac death, necessitating optimal management strategies.
Area of Science:
- Cardiology
- Developmental Biology
- Clinical Medicine
Background:
- Mitral valve prolapse (MVP), also termed floppy mitral valve syndrome, is a developmental anomaly affecting 2-3% of the general population.
- It is the primary cause of mitral regurgitation (MR) in developed nations.
- Despite being generally benign, MVP carries a risk of sudden cardiac death.
Purpose of the Study:
- To review the current understanding of benign and arrhythmic MVP (AMVP).
- To discuss diagnostic approaches for MVP.
- To explore potential management strategies for patients with MVP.
Main Methods:
- Literature review of studies on mitral valve prolapse.
- Analysis of diagnostic criteria and imaging modalities for MVP.
- Evaluation of current and emerging treatment options for MVP.
Main Results:
- MVP is a common condition, frequently leading to MR.
- The association between MVP and sudden cardiac death warrants careful consideration.
- Management strategies range from observation to pharmacological and surgical interventions.
Conclusions:
- MVP requires a nuanced approach to management, balancing its benign nature with potential risks.
- Further research is needed to refine diagnostic and therapeutic strategies for AMVP.
- Optimal patient care involves individualized treatment plans based on risk stratification.
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