Related Experiment Video
Updated: Jan 15, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Selective electrochemical trifluoromethylation of arylamide- or aryl-substituted pyrrole derivatives
Zhanshuo Zhang1, Yangkai Dong1, Yaxin Liu1
1Shandong Key Laboratory of Life-Organic Analysis, Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, P. R. China. ylzhao@qfnu.edu.cn.
Abstract:
A selective electrochemical trifluoromethylation reaction for pyrroles, particularly those containing additional aryl groups, has been developed for the synthesis of 2-trifluoromethylpyrrole derivatives. The cost-effective CF3SO2Na has been employed in the electrochemical trifluoromethylation of pyrroles using an undivided electrolytic cell under transition-metal-free conditions. This approach demonstrates that arylamide-substituted or aryl-substituted pyrrole derivatives exhibit favorable regioselectivity and site selectivity under electrochemical oxidation conditions. Additionally, this study contributes to the ongoing development and understanding of electrochemical trifluoromethylation methodologies.
More Related Videos
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Electrophilic Aromatic Substitution: Friedel–Crafts Acylation of Benzene
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Nucleophilic Aromatic Substitution: Elimination–Addition