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TRPM2: a pivotal player in tumor progression and a promising therapeutic target

Zhigang Chen1, Zhengheng Wu2, Tianhan Xu1

  • 1Department of Gastrointestinal Surgery, Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, No.68 Gehu Road, Wujin District, Jiangsu, 213000, Changzhou, China.

Cancer Cell International
|October 15, 2025
PubMed

Insights

The Transient Receptor Potential Melastatin 2 (TRPM2) channel, activated by ADP-ribose, is linked to cancer progression. Targeting TRPM2 offers potential for novel cancer therapies and diagnostics.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Transient Receptor Potential Melastatin 2 (TRPM2) is a ubiquitously expressed cation channel crucial for calcium homeostasis.
  • Elevated TRPM2 expression is increasingly associated with various cancer types and poor patient prognosis.
  • TRPM2 influences cellular proliferation, invasion, mitochondrial function, and cell cycle regulation, all vital in tumor development.

Purpose of the Study:

  • To review the role of the TRPM2 channel in tumor development.
  • To highlight TRPM2 as a potential therapeutic target for cancer treatment.
  • To explore TRPM2's utility in cancer diagnostics.

Main Methods:

  • Literature review of studies investigating TRPM2 expression and function in cancer.
  • Analysis of the correlation between TRPM2 levels and cancer progression markers.
  • Examination of preclinical and clinical data on TRPM2 modulation in cancer models.

Main Results:

  • Increased TRPM2 expression correlates with enhanced cancer cell proliferation, invasion, and migration.
  • TRPM2 plays a key role in regulating intracellular calcium levels, impacting mitochondrial function and cell cycle.
  • TRPM2 modulation demonstrates potential in inhibiting angiogenesis and overcoming chemotherapy resistance.

Conclusions:

  • TRPM2 channel is a significant factor in tumor development and progression.
  • Targeting TRPM2 presents a promising therapeutic strategy for inhibiting cancer growth and metastasis.
  • TRPM2 modulation may serve as a valuable tool in the diagnosis and treatment of various tumors.
Keywords:
ClinicalPrognosisTRPM2TargetTumor

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