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Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
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High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Therapy in Amyotrophic Lateral Sclerosis: Study

Edna Karla Ferreira Laurentino1,2, Vinicius Zacarias Maldaner da Silva3, Wesley Ribeiro Costa Meneses1,2

  • 1PneumoCardioVascular Lab/HUOL, Departamento de Fisioterapia, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal 59010-090, Rio Grande do Norte, Brazil.

Journal of Clinical Medicine
|October 16, 2025
PubMed
Summary

Home-based High-Definition Transcranial Direct Current Stimulation (HD-tDCS) may improve respiratory function in Amyotrophic Lateral Sclerosis (ALS) patients. This study evaluates HD-tDCS

Keywords:
home-based treatmentneuromuscular diseasestranscranial electrical stimulation

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Area of Science:

  • Neurology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease causing motor neuron loss and respiratory failure.
  • High-Definition Transcranial Direct Current Stimulation (HD-tDCS) shows potential in modulating motor cortical excitability.
  • Investigating non-pharmacological interventions for respiratory support in ALS is crucial.

Purpose of the Study:

  • To evaluate the effects of home-based HD-tDCS on respiratory parameters in ALS patients.
  • To assess the impact of HD-tDCS on disease progression and motor function.
  • To explore the feasibility of home-based neuromodulation for ALS management.

Main Methods:

  • Multicenter, randomized, controlled clinical trial design.
  • Participants receive daily 30-minute HD-tDCS sessions (active or sham) for two weeks.
  • Intervention targets the diaphragmatic motor cortex using a 4x1 ring configuration.

Main Results:

  • Comprehensive pre-, intra-, and post-intervention assessments.
  • Measures include cortical excitability, perfusion, respiratory function, motor performance, and quality of life.
  • Safety monitoring and adverse effect tracking are integral.

Conclusions:

  • This study will determine the efficacy of HD-tDCS for respiratory and motor function in ALS.
  • It will assess the viability of delivering neuromodulation interventions at home.
  • Findings may inform new strategies for respiratory care in ALS patients.