Does Toothache Before a Dental Visit Associate with the Risk of a First Myocardial Infarction?
Dan Sebring1, Kåre Buhlin2,3, Thomas Kvist1
1Department of Endodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Journal of Clinical Medicine
|October 16, 2025
Summary
Seeking dental care for toothache before a first myocardial infarction (MI) was not linked to increased cardiac risk. This study found no association between dental visits for tooth pain and subsequent heart attack risk in patients.
Area of Science:
- Cardiology
- Dental Medicine
- Public Health
Background:
- Ischemic heart disease can present with atypical symptoms, including orofacial pain, potentially delaying diagnosis and leading to unnecessary dental interventions.
- Orofacial symptoms associated with cardiac disease require careful evaluation to differentiate from primary dental issues.
Purpose of the Study:
- To investigate the occurrence of toothache or other oral problems prompting dental visits before a first myocardial infarction (MI).
- To determine if seeking dental care for oral pain is associated with an increased risk of a subsequent MI.
Main Methods:
- A case-control study (PAROKRANK) involving 805 patients hospitalized for a first MI and 805 matched controls.
- Participants completed surveys on dental service use, focusing on reasons for their most recent dental visit, including toothache.
- Data included medical and oral examinations, panoramic radiography, and blood sampling.
Main Results:
- The mean time since the last dental visit was 1.08 years, with no significant difference between MI patients and controls.
- Routine dental examination was the reason for visit for 80.9% of responders.
- Toothache prompted dental visits in 11.5% of respondents (10.9% of patients, 12.1% of controls), with no statistically significant difference between groups (p = 0.59).
Conclusions:
- Seeking dental care for toothache was not found to be associated with an increased risk of a first myocardial infarction.
- The study suggests that orofacial pain prompting dental visits does not serve as a predictor for future cardiac events within the study's limitations.
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