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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

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Published on: September 6, 2012

Comparison of Different Aliphatic Polyester-Based Microparticles as Protein Delivery Systems.

Viktor Korzhikov-Vlakh¹, Ekaterina Sinitsyna^1,2, Mariia Stepanova²

¹Institute of Chemistry, Saint-Petersburg State University, 198504 St. Petersburg, Russia.

|October 16, 2025

Summary

This summary is machine-generated.

This study explores how polymer properties like crystallinity and hydrophobicity affect protein-loaded microparticles. Findings guide the development of advanced drug delivery systems for biopharmaceuticals.

Keywords:

aliphatic polyesters drug release microparticles protein encapsulation ring-opening polymerization

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Area of Science:

Biomaterials Science
Polymer Chemistry
Pharmaceutical Sciences

Background:

Biopharmaceutical encapsulation is crucial for drug delivery.
Aliphatic polyesters offer tunable properties for microparticle fabrication.
Understanding polymer influence on protein stability and release is vital.

Purpose of the Study:

To investigate the impact of aliphatic polyester physicochemical properties (crystallinity, hydrophobicity) on protein-loaded microparticle development.
To compare the encapsulation, release, and activity of model proteins (BSA, α-chymotrypsin) within different polyester matrices.
To elucidate protein release mechanisms using mathematical modeling.

Main Methods:

Synthesis of amorphous (PDLLA) and semicrystalline (PLLA, PCL, PPDL) polyesters via ring-opening polymerization.
Fabrication of protein-loaded microparticles using a double emulsion solvent evaporation method.
Characterization of microparticle size, enzymatic degradation, protein encapsulation efficacy, release rates, and retained enzyme activity.

Main Results:

Polyester crystallinity and hydrophobicity significantly influenced microparticle characteristics and protein behavior.
Enzymatic degradation rates varied among the tested polyesters.
Protein encapsulation efficacy and release kinetics differed based on the polymer matrix, impacting enzyme activity retention.

Conclusions:

Aliphatic polyester properties critically affect the performance of protein-loaded microparticles.
Tailoring polyester characteristics is key to optimizing biopharmaceutical encapsulation and controlled release.
This research provides insights for designing effective protein-eluting delivery systems.