Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autophagy

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...

Allergic Reactions

Allergic Reactions

Delivery Pathways to the Lysosome

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...

Autophagic Cell Death

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Cross-reactivity

Cross-reactivity

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich's ataxia.

Molecular cell·2026

Same author

How to Employ Trained Immunity and Trained Immunity-Based Vaccines to Inhibit Allergic Inflammation.

Vaccines·2026

Same author

A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding.

Science advances·2026

Same author

MeCP2 interacts with the super elongation complex to regulate transcription.

Science advances·2025

Same author

Efficacy and Safety of Rosuvastatin/Amlodipine FDC in Patients With Hypertension and Dyslipidemia: A Multicenter, Prospective, Observational Study.

Clinical therapeutics·2025

Same author

S1PR2-miR-212 feedback loop regulates allergic reactions.

Molecular immunology·2025

Search research articles

Related Experiment Video

Updated: Jan 15, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

Crosstalk Between Allergic Inflammation and Autophagy.

Jaewhoon Jeoung¹, Wonho Kim¹, Dooil Jeoung¹

¹Department of Biochemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.

International Journal of Molecular Sciences

|October 16, 2025

Summary

This summary is machine-generated.

Autophagy regulates allergic inflammation by affecting inflammatory mediator secretion and mast cell activation. Targeting autophagy and oxidative stress may offer new anti-allergy treatments.

Keywords:

allergy autophagy crosstalk mitochondria mitophagy

More Related Videos

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Study of Protein-protein Interactions in Autophagy Research

Study of Protein-protein Interactions in Autophagy Research

Published on: September 9, 2017

Related Experiment Videos

Last Updated: Jan 15, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Study of Protein-protein Interactions in Autophagy Research

Study of Protein-protein Interactions in Autophagy Research

Published on: September 9, 2017

Area of Science:

Cellular Biology
Immunology
Molecular Medicine

Background:

Autophagy is a fundamental cellular process crucial for maintaining homeostasis by degrading damaged components.
It plays significant roles in immune responses, pathogen defense, and notably, the development and progression of allergic inflammation.
The interplay between autophagy and signaling pathways critically influences immune reactions to inflammatory cues.

Purpose of the Study:

To elucidate the regulatory functions of autophagy in the context of allergic inflammation.
To explore the dual role of autophagy, both promoting and exacerbating allergic responses.
To investigate the connection between mitophagy, mast cell activation, and allergic diseases.

Main Methods:

Literature review and synthesis of current research on autophagy in allergic inflammation.
Analysis of signaling pathways and molecular mechanisms involved in autophagy-related allergic responses.
Discussion of the role of mitochondrial dynamics (mitophagy) in mast cell activation.

Main Results:

Autophagy can potentiate allergic inflammation through enhanced secretion of inflammatory mediators.
Dysfunctional autophagy, marked by autophagosome accumulation, can worsen allergic inflammation.
Mast cell activation, crucial in allergies, involves mitochondrial fragmentation and mitophagy, influenced by oxidative stress.

Conclusions:

Autophagy significantly modulates allergic inflammation, with both beneficial and detrimental effects.
Mitophagy and oxidative stress are closely linked to mast cell activation in allergic conditions.
Targeting autophagy and oxidative stress pathways presents a promising therapeutic strategy for developing novel anti-allergy drugs.