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Updated: Jan 15, 2026
Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research
Published on: December 1, 2023
Brain-Bone Axis in Physiological and Pathological Conditions
Luca Massaccesi1,2, Massimiliano Marco Corsi Romanelli1,3, Emanuela Galliera1,2
1Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.
Abstract:
The brain-bone axis has garnered increasing attention over the years, leading to numerous studies that have unraveled the intricate bidirectional communication between the central nervous system (CNS) and skeletal metabolism. This review explores this profound relationship, examining the complex mechanisms that regulate it, the key players involved, and the clinical implications of its dysfunction in various pathological situations affecting the CNS and skeletal system. Ultimately, it emphasizes the potential of ongoing research to develop diagnostic tools, therapeutic interventions, and preventive strategies aimed at enhancing skeletal and neurological health.
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