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Beyond the Skin: Atopic Dermatitis and Increased Gastric Cancer Risk in Korea
Ho Suk Kang1, Kyeong Min Han2, Joo-Hee Kim3
1Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Cancers
|October 16, 2025
Summary
Atopic dermatitis (AD) is linked to a higher risk of gastric cancer (GC). This study suggests that skin inflammation might play a role in GC development, emphasizing the need for integrated health approaches.
Area of Science:
- Dermatology and Oncology
- Epidemiology
- Public Health
Background:
- Atopic dermatitis (AD) is a common chronic inflammatory skin condition.
- The association between AD and gastric cancer (GC) is not well understood.
- Investigating this link is crucial for understanding potential systemic health implications of AD.
Purpose of the Study:
- To examine the relationship between atopic dermatitis and the risk of developing gastric cancer.
- To utilize a large-scale Korean population database for robust statistical analysis.
- To identify specific demographic or clinical factors that may modify this association.
Main Methods:
- A nested case-control study design was employed.
- Data from the Korean National Health Insurance Service-National Sample Cohort included 10,174 GC patients and 40,696 controls.
- Overlap propensity score weighting and logistic regression were used to adjust for potential confounders.
Main Results:
- Atopic dermatitis was significantly associated with an increased risk of gastric cancer (adjusted OR = 1.08).
- Stronger associations were observed in older adults (≥65 years), men, and rural residents.
- Individuals with non-allergic rhinitis or without asthma showed elevated GC risks.
Conclusions:
- Atopic dermatitis may be a risk factor for gastric cancer in the Korean population.
- These findings suggest a potential link between dermatological conditions and systemic cancer risk.
- Further research is warranted to elucidate the underlying mechanisms connecting AD and GC.
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