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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Related Experiment Video

Updated: Jan 15, 2026

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
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Local Recurrence After Nephron Surgery: What to Do? An Italian Multicentric Registry.

Angelo Porreca1,2, Filippo Marino1, Davide De Marchi1

  • 1Department of Urology, Humanitas Gavazzeni, 24125 Bergamo, Italy.

Cancers
|October 16, 2025
PubMed
Summary
This summary is machine-generated.

Local recurrence (LR) after renal cell carcinoma (RCC) surgery is a challenge. Positive surgical margins and specific tumor variants independently predict LR, highlighting the need for vigilant follow-up and multidisciplinary care.

Keywords:
local recurrencepartial nephrectomypositive surgical marginprognostic factorradical nephrectomyrenal cell carcinomareview

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Area of Science:

  • Urology
  • Oncology
  • Surgical Pathology

Background:

  • Local recurrence (LR) following surgical treatment for renal cell carcinoma (RCC) presents a persistent clinical challenge.
  • Identifying risk factors and optimizing management strategies for LR are crucial for improving patient outcomes.

Purpose of the Study:

  • To identify relative risk factors associated with local recurrence (LR) after surgery for renal cell carcinoma (RCC).
  • To explore optimal clinical management strategies for patients experiencing local recurrence (LR).

Main Methods:

  • A retrospective, multicentric registry study involving Italian urological centers.
  • Inclusion of patients who underwent nephron-sparing or radical nephrectomy and subsequently developed LR.
  • Exclusion of patients with hereditary syndromes or metastatic disease at LR diagnosis.

Main Results:

  • Analysis of 135 LR cases revealed key characteristics of primary tumors and surgical interventions.
  • Positive surgical margins (PSM) and specific histological variants were identified as independent predictors of LR, with significant relative risks.
  • Surgical management of LR demonstrated superior oncological control and survival rates compared to other treatment modalities.

Conclusions:

  • Local recurrence (LR) after nephron-sparing or radical nephrectomy for renal cell carcinoma (RCC) poses a significant clinical dilemma.
  • Current risk factors are insufficient for precise prediction, necessitating adherence to radiological follow-up guidelines.
  • Early detection and a multidisciplinary approach involving expert centers are vital for optimizing outcomes in LR cases.