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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Adverse Reactions Following Intradermal Injection of Exosome-Based Formulations: A Case Series.

Kui Young Park1

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|October 16, 2025
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Summary

Unregulated exosome injections in aesthetic dermatology can cause severe skin reactions like persistent inflammation and scarring. This highlights the urgent need for regulatory oversight and patient education to prevent adverse events.

Keywords:
adverse reactioncosmetic injectionexosomesgranuloma

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Area of Science:

  • Dermatology
  • Cosmetic Science
  • Regenerative Medicine

Background:

  • Exosome-containing formulations are popular in aesthetic dermatology for purported regenerative and anti-inflammatory effects.
  • Intradermal injection of these cosmetic products is an off-label, unregulated practice in many regions, including South Korea.

Purpose of the Study:

  • To report on severe cutaneous adverse reactions (SCARs) resulting from the intradermal injection of unregulated exosome-based formulations.
  • To document the clinical presentation, management, and outcomes of affected patients.

Main Methods:

  • Case series describing four adult women who received intradermal injections of exosome products in nonclinical settings.
  • Documentation of clinical course, including erythema, nodules, granulomatous inflammation, and scarring.
  • Review of treatment modalities and patient outcomes.

Main Results:

  • All patients presented with persistent inflammatory skin lesions following exosome injections.
  • Treatment involved systemic and intralesional corticosteroids, laser therapy, and surgical excision.
  • Outcomes were characterized by incomplete resolution and significant residual scarring in all cases.

Conclusions:

  • Intradermal administration of unapproved exosome formulations can lead to serious, persistent cutaneous complications.
  • Emphasizes the critical need for regulatory action, enhanced practitioner education, and public awareness regarding the risks of off-label use.
  • Highlights the importance of patient safety in aesthetic dermatology practices.