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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.1K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Jan 15, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
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Recent progress on DNA methylation in psoriasis.

Zhaoping Lin1,2,3, Xiaoting Wu4,5, Xuqin Hong6

  • 1Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Frontiers in Genetics
|October 16, 2025
PubMed
Summary
This summary is machine-generated.

Epigenetics, specifically DNA methylation (DNAm), is increasingly important in understanding psoriasis. Research highlights DNAm alterations as key players in psoriasis development and potential therapeutic targets.

Keywords:
DNA methylationepigeneticspathogenesisprogresspsoriasis

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Area of Science:

  • Dermatology and Immunology
  • Epigenetics
  • Molecular Biology

Background:

  • Psoriasis is a chronic inflammatory skin disease influenced by genetic, immunological, and environmental factors.
  • Epigenetics, heritable changes in gene expression without altering DNA sequence, is a rapidly advancing research area in psoriasis.
  • DNA methylation (DNAm) is the most common epigenetic mechanism and is extensively studied.

Purpose of the Study:

  • To review and summarize recent advancements in understanding DNA methylation in psoriasis pathogenesis.
  • To highlight the role of DNAm alterations in the development of psoriasis.
  • To identify potential therapeutic targets for psoriasis based on DNAm.

Main Methods:

  • Literature review of recent studies on DNA methylation and psoriasis.
  • Analysis of research focusing on epigenetic modifications in psoriatic lesions.
  • Synthesis of findings on differentially methylated sites in psoriasis.

Main Results:

  • DNA methylation plays a significant role in the pathogenesis of psoriasis.
  • Aberrant DNAm patterns are observed in individuals with psoriasis.
  • Specific differentially methylated sites show potential as therapeutic targets.

Conclusions:

  • DNA methylation is a critical factor in psoriasis development.
  • Targeting DNAm alterations offers promising therapeutic strategies for psoriasis.
  • Continued research into epigenetic mechanisms is vital for advancing psoriasis treatment.