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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
A glutathione-activated programmable DNA device for visual microRNA-210-enhanced photodynamic therapy of hypoxic lung
Xiangdan Meng1, Sirong Sun2, Xueji Zhang3
1Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Abstract:
In this study, we construct a glutathione (GSH)-activated DNA nanodevice conjugated to a porphyrin-based metal-organic framework (PCN-224), creating an integrated theranostic platform for modulating hypoxia, enabling miRNA-210-specific imaging and enhancing photodynamic therapy (PDT).
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