Related Experiment Video
Updated: Jan 14, 2026

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate
Published on: June 18, 2020
Manganese-based nanozymes for the dynamic regulation of the osteogenic microenvironment
Xinlin Li1, Binmian Shi1, Yupu Lu1
1Department of Dental Materials, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Abstract:
In recent years, manganese-based nanozymes (MBNs)-featuring the combined advantages of nanomaterial properties, manganese-specific characteristics, and multi-enzyme mimetic activities-have demonstrated revolutionary potential in modulating the osteogenic microenvironment. This work systematically reviews the multidimensional regulatory pathways by which MBNs modulate the osteogenic microenvironment, including dynamic regulation of reactive oxygen species (ROS), remodelling of the immune microenvironment, synergistic promotion of neurovascularisation, antibacterial activity and infection control, and regulation of osteogenic cell fate. Additionally, the review outlines their specific applications in various pathological contexts, such as infected bone defects, osteosarcoma, osteoporosis, and periodontitis. Finally, the current challenges hindering the clinical translation of MBNs are critically analysed, and precision-oriented strategies for their development are proposed. These insights are pivotal for advancing the clinical translation of MBNs, particularly in treating refractory bone defects.
More Related Videos
09:35Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
08:28A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
Published on: May 21, 2020
Related Concept Videos
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling
Osteoclasts in Bone Remodeling
Allosteric Regulation