Related Experiment Video
Updated: Jan 14, 2026

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
Published on: July 3, 2025
Friendship fights cancer
Antonio V Aubry1, Scott J Russo1
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Brain-Body Research Institute and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abstract:
In this issue of Neuron, Wen et al.1 reveal that social interaction activates an ACC→BLA circuit in female breast cancer model mice, reducing anxiety, norepinephrine, and tumor growth. Circuit manipulations shift immunity toward cytotoxic T cells, uncovering a brain-immune pathway translating companionship into antitumor effects.
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