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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Related Experiment Video

Updated: Jan 14, 2026

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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Friendship fights cancer.

Antonio V Aubry1, Scott J Russo1

  • 1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Brain-Body Research Institute and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Neuron
|October 16, 2025
PubMed
Summary

Social interaction in female mice with breast cancer activates a brain circuit, reducing anxiety and tumor growth. This brain-immune pathway boosts cytotoxic T cells for antitumor effects.

Area of Science:

  • Neuroscience
  • Immunology
  • Oncology

Background:

  • Social interaction is known to influence health outcomes.
  • The brain-immune axis plays a critical role in disease progression.

Purpose of the Study:

  • To investigate the neural circuits underlying the effects of social interaction on breast cancer progression.
  • To explore the link between social behavior, brain activity, and antitumor immunity.

Main Methods:

  • Utilized female breast cancer model mice.
  • Employed circuit manipulation techniques to activate the ACC→BLA pathway.
  • Assessed anxiety levels, norepinephrine, tumor growth, and immune cell profiles, specifically cytotoxic T cells.

Main Results:

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  • Social interaction activated a specific circuit (ACC→BLA) in mice with breast cancer.
  • Activation of this circuit led to reduced anxiety, lower norepinephrine levels, and decreased tumor growth.
  • Circuit manipulation shifted the immune response towards an increase in cytotoxic T cells.

Conclusions:

  • A direct brain-immune pathway exists where social interaction translates into antitumor effects.
  • The ACC→BLA circuit is a key mediator of social interaction's impact on cancer immunity.
  • Targeting this brain-immune pathway holds potential for novel cancer therapies.