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Updated: Jan 14, 2026

Artificial Intelligence Approaches to Assessing Primary Cilia
Published on: May 1, 2021
Comparison of Qualitative Analyses Conducted by Artificial Intelligence Versus Traditional Methods
Marcela Salazar1, May Chaw1, Yvette Hellier1
1University of California San Francisco School of Pharmacy, Department of Clinical Pharmacy, San Francisco, CA, USA.
Objective:
Qualitative research remains underutilized in health professions education, in part due to insufficient training and time-intensive analytic methods. Recent advances in generative artificial intelligence offer new opportunities to streamline the qualitative research process using large language models such as GPT-4. However, the accuracy of GPT-4-generated codes and themes remains underexplored in health professions education research. This study characterizes qualitative analyses assisted by a general-purpose GPT-4 compared to traditional human-conducted analyses.
Methods:
Two health professions datasets were previously analyzed using content or thematic analysis and then reanalyzed using a version of GPT-4. Researchers compared the accuracy, alignment, relevance, and appropriateness of codebooks and themes produced by GPT-4 with the prior findings. Dichotomous numerical ratings and explanations were assessed independently and then discussed collaboratively to identify strengths and weaknesses associated with GPT-4 qualitative analysis.
Results:
In total, 36 survey responses and seven 1-h interview transcripts were analyzed using GPT-4. The codebooks and themes generated by GPT-4 generally aligned with human-identified concepts. Challenges included failure to detect low-frequency codes, difficulty constructing coherent code relationships, and a lack of nuance in theme descriptions and quote selection.
Conclusion:
GPT-4 can support, though not replace, human-led qualitative analysis. A general understanding of qualitative research processes and the dataset is necessary for researchers to identify potential gaps, limitations, and redundancies in qualitative findings generated by GPT-4.
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