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Matthew Hakim Nasra1, Abhinaba Chatterjee1, Kenneth Zaslav1

  • 1Department of Orthopedic Surgery, Lenox Hill Hospital, 130 East 77th Street, New York, NY 10075, USA.

Clinics in Sports Medicine
|October 16, 2025
PubMed

Keywords:
CartilageCorticosteroidHyaluronic acidIntra-articular injectionOsteoarthritis

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
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