Clinical and Family Conversations Regarding Genetic Testing: A Case Study of Uncertainty Management.

Area of Science:

• Genetics
• Oncology
• Communication Studies

Background:

• Cancer-related genetic testing (CGT) involves complex results, such as variants of uncertain significance (VUS).
• Effective communication of CGT results and uncertainty between patients, clinicians, and families is crucial for informed decision-making and emotional support.

Purpose of the Study:

• To compare communication content in clinical and family settings regarding cancer-related genetic testing (CGT).
• To explore how patients with ovarian cancer and their families manage uncertainty following a VUS result.

Main Methods:

• Qualitative analysis of video-recorded genetic counseling and family conversations.
• Survey responses assessing patient and family emotions and communication satisfaction.
• Utilized uncertainty management theory to interpret findings.

Main Results:

• Identified four key themes: emotions talk, family talk, expressing uncertainty, and managing uncertainty.
• Demonstrated the interconnectedness of scientific information, test interpretation, recommendations, and family implications in managing uncertainty.
• Patients reported higher anxiety and fear than family members, underscoring the emotional nature of uncertainty and the importance of social support.

Conclusions:

• Uncertainty in CGT is multifaceted, encompassing emotional and informational aspects.
• Findings can inform the development of strategies to improve patient-family communication about CGT results.
• Enhanced communication support is needed for patients navigating VUS results and their familial implications.