Related Experiment Video
Updated: Jan 14, 2026
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Mechanical Thrombectomy in Two Children Under the Age of One Year
Erensu Mengüşoğlu1, Francesco Puccinelli2, Steven D Hajdu2
1Department of Neurology Kartal Lütfi Kırdar City Hospital Istanbul Turkey.
Insights
Mechanical thrombectomy (MT) is a viable treatment for infants experiencing stroke complications during retinoblastoma treatment. This study shows MT is safe and effective, achieving full artery reopening and normal neurological outcomes in two young patients.
Area of Science:
- Pediatric Neurology
- Interventional Neuroradiology
- Ophthalmology
Background:
- Mechanical thrombectomy (MT) is rarely performed in infants due to limited data and ethical considerations.
- Thromboembolic complications can occur during intra-arterial chemotherapy for retinoblastoma in infants.
- Infantile stroke presents unique challenges for treatment and management.
Purpose of the Study:
- To evaluate the feasibility and safety of mechanical thrombectomy (MT) with thromboaspiration in infants.
- To assess the outcomes of MT in two infants experiencing thromboembolic events during retinoblastoma treatment.
- To contribute to the limited data on MT in pediatric stroke management.
Main Methods:
- Case series review of two infants under one year old undergoing mechanical thrombectomy.
- Procedure involved thromboaspiration for arterial occlusion.
- Outcomes assessed via recanalization (eTICI score), infarction/hemorrhage on imaging, and neurological status (pedNIHSS).
Main Results:
- Successful full recanalization (eTICI=3) was achieved in both infant cases.
- No instances of infarction or hemorrhage were observed post-procedure.
- Both patients demonstrated normal neurological outcomes (pedNIHSS=0) with no complications.
Conclusions:
- Mechanical thrombectomy (MT) is a feasible and safe intervention for infants with arterial occlusions.
- MT can lead to excellent neurological outcomes in high-risk pediatric cases.
- Further research is warranted to develop standardized guidelines for MT in pediatric stroke.
Abstract:
This case series examines mechanical thrombectomy (MT) with thromboaspiration in two infants under 1 year, a rarely performed procedure due to ethical challenges and limited data. Both cases involved thromboembolic complications during intra-arterial chemotherapy for retinoblastoma. An 11-month-old with left posterior inferior cerebellar artery occlusion and a 5-month-old with basilar artery occlusion underwent MT, achieving full recanalization (eTICI = 3) without infarction or hemorrhage. Postoperative imaging confirmed no complications, and both patients had normal neurological outcomes (pedNIHSS = 0). These cases highlight the feasibility and safety of MT in infants, demonstrating its potential to achieve excellent outcomes in high-risk situations. Further research is needed to establish standardized guidelines and expand MT's use in pediatric stroke management.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care