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Updated: Jan 14, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Three-Component Copper-Catalyzed 1,4-Carboamination of 1,3-Dienes
Siyuan Shi1, Zonglei Guo1, Yanyan Li2
1School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Abstract:
We herein report a highly selective copper-catalyzed three-component 1,4-carboamination of 1,3-dienes with activated alkyl bromides and amines, providing a general and practical route to functionalized allylamine derivatives. This operationally simple protocol demonstrates a broad substrate scope (>45 examples), good functional group tolerance, and high E/Z ratio selectivity. The synthetic utility of this method was further exemplified by its successful application in the late-stage functionalization of various bioactive molecules.
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