Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 14, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.9K

Clinical validation of embryo prognostic tests; determining predictive value: phase 2.

Paul Pirtea1, Irene H Su2, Christian Liebst Frisk Toft3

  • 1Department of Obstetrics and Gynecology and Reproductive Medicine, Hospital Foch, France.

Fertility and Sterility
|October 17, 2025
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Complete Embryo Developmental Arrest and Its Prognostic Significance in IVF.

Fertility and sterility·2026
Same author

Recurrent assisted reproductive technology failure: the embryo perspective.

Fertility and sterility·2026
Same author

Can a focus on intracellular signaling assist us with ovarian stimulation in poor-prognosis patients?

Fertility and sterility·2026
Same author

Not all adenomyosis is equal: impact of direct adenomyosis features on live birth after ART cycles in a prospective cohort study.

Frontiers in endocrinology·2026
Same author

An advanced SWOT analysis of elective vitrification: today's standard IVF procedure.

Reproductive biomedicine online·2026
Same author

Euploidy rates are comparable between progestin protocol ovarian stimulation and gonadotropin-releasing hormone antagonist protocol ovarian stimulation cycles.

Fertility and sterility·2026

Validating clinical embryo tests, such as preimplantation genetic tests, requires understanding unique challenges. This study outlines a methodology for effective validation to ensure safe and accurate prognostic and diagnostic embryo testing.

Area of Science:

  • Reproductive Medicine
  • Clinical Embryology
  • Genetic Testing

Background:

  • Clinical tests, including those for embryo competence, must be safe and effective.
  • Validating tests for human embryos presents unique challenges compared to other clinical tests.
  • Effective validation paradigms are crucial for reliable embryo testing.

Purpose of the Study:

  • To detail the methodology for performing clinical validation of embryo tests.
  • To address the challenges specific to validating tests on human embryos.
  • To provide a framework for designing and implementing effective embryo test validation.

Main Methods:

  • Discussion of prognostic versus diagnostic test concepts.
  • Consideration of mosaicism and appropriate endpoint measures.
Keywords:
ARTPGT-aclinical testsembryo prognosticsvalidation study

More Related Videos

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

23.5K
Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
05:13

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

1.6K

Related Experiment Videos

Last Updated: Jan 14, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.9K
Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

23.5K
Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
05:13

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

1.6K
  • Guidance on study design, sample size, patient cohorts, blinding, and data analysis.

    • Main Results:

    • Preimplantation genetic tests serve as a practical example due to their widespread use.
    • The manuscript covers key aspects of validation methodology.
    • Understanding challenges is essential for effective validation.

    Conclusions:

    • A robust validation methodology is essential for clinical embryo tests.
    • This manuscript provides a comprehensive guide to embryo test validation.
    • Effective validation ensures the safety and efficacy of embryo testing for reproductive outcomes.