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Updated: Jan 14, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Decoding the mechanism for cytotoxicity in thiolato-bridged triosmium carbonyl clusters: from serum reactivity to
Xin Liang1, Hélène C Bertrand2, Nicolas Delsuc2
1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, 637371, Singapore.
Abstract:
Mechanism of action (MoA) studies on the cytotoxic thiolato-bridged triosmium carbonyl clusters Os3(CO)10(μ-H)(μ-SR) (2) indicates that their cytotoxicity is associated with increased reactive oxygen species (ROS) generation, G2/M cell cycle arrest, and subsequent apoptosis. Cellular uptake is a key factor, with an increased reactivity of the cluster with serum leading to reduced available concentrations in the medium thereby diminishing its anti-proliferative effect. Reactivity studies reveal that biomolecular interactions occur predominantly at the triosmium core, with a preference for amine-containing species.
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