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Maternal Attention Deficit Hyperactivity Disorder and Perinatal Depression: A Systematic Review
Natalie Pierotti1, Kaushadh Jayakody1,2,3
1Bendigo Health, Bendigo, VIC, Australia.
Journal of Attention Disorders
|October 18, 2025
Summary
Women with Attention Deficit Hyperactivity Disorder (ADHD) face a significantly higher risk of perinatal depression. This systematic review highlights the association between ADHD symptoms and increased vulnerability to depression during the perinatal period.
Area of Science:
- Perinatal Mental Health
- Neurodevelopmental Disorders
- Psychiatry
Background:
- Attention Deficit Hyperactivity Disorder (ADHD) is a persistent condition often comorbid with other mental health issues.
- Limited research exists on ADHD in the perinatal period, despite increasing diagnoses in women of reproductive age.
Purpose of the Study:
- To critically appraise existing literature on the association between maternal ADHD and perinatal depression.
- To examine the prevalence and risk factors of perinatal depression in women with ADHD.
Main Methods:
- A systematic review was conducted using EMBASE, PsycINFO, MEDLINE, and Google Scholar.
- Literature was evaluated using PRISMA guidelines and quality assessed with the Joanna Briggs Institute framework.
- A narrative synthesis of ten included studies was performed.
Main Results:
- A prevalence of 16.76% to 57.6% for perinatal depression was found in women with ADHD.
- Women with ADHD showed an increased risk of perinatal depression (OR 1.8-2.63).
- A positive association was observed between ADHD symptoms and depressive symptoms in the perinatal period.
Conclusions:
- Women with ADHD exhibit greater vulnerability to perinatal depression.
- A clear association exists between ADHD symptoms and depressive symptoms during the perinatal period.
- Further high-quality research is needed to validate these findings.
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