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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Novel Therapeutics for Hepatocellular Carcinoma

Mohamed I Elsaid1, Ashish Manne2

  • 1Division of Biostatistics and Population Health, Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA; Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA; Cancer Control, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Clinics in Liver Disease
|October 18, 2025
PubMed
Summary

Advances in hepatocellular carcinoma (HCC) treatment, including immunotherapy and targeted therapies, are improving survival. Precision oncology and addressing access barriers mark a new era of personalized HCC care.

Keywords:
FGFR4 inhibitionFerroptosis inductionImmunotherapyLiquid biopsyNext-generation checkpoint inhibitorsPrecision oncologyβ-catenin modulation

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