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Updated: Jan 14, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Gamma delta T cells: Multifaceted mediators in pregnancy and the pathogenesis of miscarriage
Qianhan Xu1, Lu Chen1, Junshang Dai1
1Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, P.R. China.
Abstract:
Pregnancy represents a unique physiological process characterized by a delicate balance between immune tolerance and immune surveillance. Gamma delta (γδ) T cells, serving as a bridge between adaptive and innate immunity, play crucial roles in the maintenance and progression of pregnancy. Alteration in the proportion, subset and function of γδT cells can contribute to miscarriage. This review provides an insightful overview of the physiological roles of γδT cells during normal pregnancy, alongside their pathological implications in miscarriage. Additionally, we explore potential research avenues leveraging γδT cells as potential therapeutic targets for miscarriage. By shedding light on the pivotal roles of γδT cells in pregnancy, this comprehensive review underscores their significance and advocates for innovative approaches to miscarriage treatment.
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