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Updated: Jan 14, 2026
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
γδ T cells and head and neck squamous cell carcinoma
Jiayu Peng1, Hui Qiu2, Lin-Lin Bu3
1School of Medicine, Wuhan University, Wuhan, P.R. China; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China; Hubei Key Laboratory of Tumor Biological Behavior, Department of Radiation and Medical Oncology, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.
Abstract:
Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive malignant tumor with poor clinical prognosis. The immune system plays a critical role in tumor surveillance and response to therapy. Among various immune cell populations, γδ T (γδ T) cells, a unique subset of lymphocytes, have emerged as significant participants in the anti-tumor immune response and have attracted extensive attention in recent studies. This chapter discusses the unique properties of γδ T cells, their role in HNSCC, and evaluates their potential value as therapeutic targets for HNSCC.
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