Molecularly imprinted polypyrrole-based POF dual sensor for dopamine detection exploiting plasmonic and voltammetric...

Area of Science:

• Analytical Chemistry
• Materials Science
• Biomedical Engineering

Background:

• Dopamine monitoring is crucial for diagnosing neurological disorders.
• Existing sensors often lack sensitivity or versatility for real-world applications.

Purpose of the Study:

• To develop a dual-mode chemical sensor for sensitive dopamine detection.
• To integrate surface plasmon resonance (SPR) and differential pulse voltammetry (DPV) for enhanced performance.

Main Methods:

• Electropolymerized molecularly imprinted polypyrrole (eMIP) on a SPR D-shaped plastic optical fiber (POF) platform.
• Utilized gold nanofilm as a plasmonic surface and working electrode.
• Real-time monitoring of eMIP deposition and template extraction via plasmonic resonance wavelength variation.

Main Results:

• Achieved excellent sensitivity for dopamine detection across picomolar to micromolar concentrations.
• Demonstrated successful dopamine detection in real biological samples (blood via SPR, urine via DPV).
• The dual-mode sensor exhibited high sensitivity and versatility.

Conclusions:

• The developed eMIP-based SPR-POF sensor offers a promising hybrid approach for dopamine monitoring.
• The sensor's dual-mode capability enhances its applicability across different sample matrices and analyte concentrations.
• This technology holds significant potential for clinical diagnostics and research.