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Body:In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
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Establishment of a Clinic-based Biorepository
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Building Up a Biomedical Research Workforce Trial.

Doris M Rubio1, Gretchen E White1, Audrey J Murrell2

  • 1Department of General Internal Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Journal of Clinical and Translational Science
|October 20, 2025
PubMed
Summary
This summary is machine-generated.

The Building Up intervention significantly increased Psychological Capital, including self-efficacy, resilience, and optimism, in biomedical researchers from underrepresented backgrounds over three years. This study offers evidence-based methods to enhance the research workforce.

Keywords:
Psychological Capitalacademic medical centerscareer advancement for underrepresented groupscareer developmentcluster randomized controlled trial

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Area of Science:

  • Biomedical research workforce development
  • Psychological Capital in science
  • Diversity and inclusion in STEM

Background:

  • Diverse research teams enhance scientific productivity.
  • There is a need for evidence-based strategies to improve the biomedical research workforce.
  • The Building Up intervention aimed to support researchers from backgrounds underrepresented in science.

Purpose of the Study:

  • To test if participants from underrepresented backgrounds randomized to the Building Up intervention would have more publications and increased Psychological Capital.
  • To evaluate the long-term impact of a multi-component intervention on researchers' psychological resources.

Main Methods:

  • A multi-center, cluster-randomized, unblinded controlled trial involving 25 academic medical centers.
  • Intervention group received 10 months of monthly meetings, near-peer mentoring, networking, and writing coursework.
  • Control group received standard institutional mentoring, networking, and coursework.

Main Results:

  • Participants in the intervention arm showed significantly higher levels of self-efficacy, resilience, and optimism.
  • These positive effects on Psychological Capital were sustained for three years post-intervention.
  • High retention rates were observed, with 71% completing the 1-year follow-up.

Conclusions:

  • The Building Up intervention effectively enhances Psychological Capital among biomedical researchers.
  • The findings support the use of targeted interventions to foster a more robust and inclusive research workforce.
  • This study provides a model for evidence-based workforce development in biomedical sciences.