Utilizing Circulating MicroRNAs for Personalized Exercise Programs: Insights into Physiological Adaptations and...

Area of Science:

• Exercise Physiology
• Molecular Biology
• Biomarkers

Background:

• Cardiomyocyte microRNAs (c-miRNAs) are small non-coding RNAs involved in gene regulation.
• Exercise induces molecular changes in the cardiovascular system and muscles.
• Understanding c-miRNA responses to exercise is crucial for optimizing training.

Purpose of the Study:

• To review current literature on exercise-related c-miRNAs.
• To identify c-miRNAs sensitive to exercise-induced adaptations.
• To explore the potential of c-miRNAs as biomarkers for personalized exercise prescriptions.

Main Methods:

• A narrative review of studies on c-miRNAs and exercise.
• Searches conducted in PubMed, Google Scholar, ScienceDirect, Web of Science, and Scopus.
• Keywords used included "microRNA," "exercise," and "biomarkers."

Main Results:

• Several c-miRNAs, including miR-1, miR-126, miR-21, and miR-146a, are significantly altered by exercise.
• These c-miRNAs correlate with cardiovascular and muscle adaptations.
• c-miRNAs show potential as indicators for individualized training programs.

Conclusions:

• c-miRNAs hold promise for developing personalized exercise prescriptions.
• Further research is needed to understand c-miRNA regulatory networks and population variability.
• Clinicians and sports practitioners can use this knowledge to refine training strategies and improve health monitoring.