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Immunoglobulin: unraveling its complex web in aging
Qiaoli Gu1, Yi Wang1, Can Zhu1
1Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China.
Frontiers in Immunology
|October 20, 2025
Summary
Immunoglobulin (Ig) levels and function change with age, impacting immunity and age-related diseases. Understanding Ig
Area of Science:
- Immunology
- Gerontology
- Molecular Biology
Background:
- Aging is a complex biological process linked to diseases like cancer and neurodegeneration.
- Immunoglobulins (Ig) are key proteins in adaptive immunity, with roles in antibody production and antigen recognition.
- Age-related changes in Ig quantity, glycosylation, and function are observed, with some Ig accumulating in aged tissues.
Purpose of the Study:
- To review current research on the relationship between Immunoglobulin (Ig) and aging.
- To discuss the interplay between B cells, gut microbiota, Ig, and the aging process.
- To explore potential therapeutic strategies targeting Ig in age-related diseases.
Main Methods:
- Literature review focusing on current research findings on Ig and aging.
- Analysis of the role of B cells in immune dysregulation during aging.
- Exploration of the connection between gut microbiota and Ig alterations in aging.
Main Results:
- Ig quantity, glycosylation, and function are altered during aging.
- Accumulation of certain Ig in aged tissues suggests a role as aging biomarkers.
- Aging affects B cells, leading to immune dysregulation, increased autoimmunity, and reduced vaccine efficacy.
Conclusions:
- Ig plays a critical role in the aging process and age-related diseases.
- The interplay between B cells, gut microbiota, and Ig is central to immune changes during aging.
- Further research into Ig regulatory mechanisms in aging may reveal therapeutic targets for age-related conditions.
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