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On-skin, micro-objective enabled camera module for speckle contrast optical spectroscopy/tomography.

Andres Quiroga1, Lorenzo Cortese1, Manish Verma1

  • 1ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain.

Biomedical Optics Express
|October 20, 2025
PubMed
Summary
This summary is machine-generated.

We developed a compact speckle contrast optical spectroscopy/tomography (SCOS/SCOT) system using micro-objectives for direct skin contact. This system accurately tracks muscle blood flow and pulsatile dynamics, paving the way for wearable SCOS/SCOT devices.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Optical Spectroscopy

Background:

  • Speckle contrast optical spectroscopy/tomography (SCOS/SCOT) is valuable for non-invasive blood flow monitoring.
  • Existing SCOS/SCOT systems often require fiber coupling, limiting portability and ease of use.
  • Development of compact, wearable SCOS/SCOT devices is crucial for continuous physiological monitoring.

Purpose of the Study:

  • To introduce and validate a novel, compact SCOS/SCOT system utilizing an integrated micro-objective array.
  • To assess the system's performance for direct skin contact measurements and simultaneous multi-distance acquisitions.
  • To demonstrate the system's capability for in vivo monitoring of muscle blood flow and pulsatile dynamics.

Main Methods:

  • An integrated imaging SCOS/SCOT configuration with 113 micro-objectives on a CMOS camera was designed, eliminating fiber coupling.
  • The system was validated ex vivo using phantoms and in vivo on human forearm muscle.
  • Measurements were performed at multiple source-detector separations and camera exposure times.

Main Results:

  • The system demonstrated excellent agreement with the correlation-diffusion model for ex vivo and in vivo measurements.
  • In vivo data showed high signal-to-noise ratio tracking of pulsatile blood flow (detecting >4 cardiac harmonics).
  • The system exhibited sensitivity to small changes in muscle blood flow.

Conclusions:

  • The micro-objective array-based SCOS/SCOT system enables direct skin contact and simultaneous multi-distance measurements.
  • This compact design overcomes a key challenge for the development of wearable SCOS/SCOT devices.
  • The validated system shows promise for advanced, non-invasive muscle blood flow monitoring.