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Updated: Jan 14, 2026

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
Published on: August 16, 2012
On-skin, micro-objective enabled camera module for speckle contrast optical spectroscopy/tomography
Andres Quiroga1, Lorenzo Cortese1, Manish Verma1
1ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain.
None:
In this paper, we introduce a speckle contrast optical spectroscopy/tomography (SCOS/SCOT) configuration based on an integrated imaging approach exploiting 113 micro-objectives mounted on a commercial CMOS camera that operates without fiber coupling, suitable for direct skin contact measurements and simultaneous multiple source-detector separation acquisitions. This compact system was validated ex vivo on phantoms and in vivo by monitoring the blood flow on the forearm muscle of a healthy human subject. The measurements, performed at multiple source-detector separations and camera exposure times, demonstrate excellent agreement with the theory based on the correlation-diffusion model. In vivo data demonstrate the capability of tracking pulsatile blood flow with a high signal-to-noise ratio (>4 harmonics of the cardiac pulse frequency detected) and sensitivity to small changes in muscle blood flow. This micro-objective array-based design overcomes a key challenge towards wearable SCOS/SCOT devices.
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