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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 14, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Decoding Corneal Endothelial Loss from Glaucoma Treatment: A Case-Control Stratification Analysis.

Christopher D Yang1, Blaze Ann C Carbonell1, Vincent Hussey1

  • 1Department of Ophthalmology, Gavin Herbert Eye Institute, UC Irvine Health, Irvine; University of California, Irvine School of Medicine, Irvine, California, United States.

Journal of Current Glaucoma Practice
|October 20, 2025
PubMed
Summary
This summary is machine-generated.

Glaucoma treatments, including drops and surgeries, significantly reduce corneal endothelial cell density. Rho-associated protein kinase inhibitors cause the most cell loss, impacting corneal health.

Keywords:
Corneal endotheliumEndothelial cell densityGlaucomaGlaucoma medicationGlaucoma surgery

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Area of Science:

  • Ophthalmology
  • Corneal Science
  • Glaucoma Research

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Corneal endothelial cells are vital for maintaining corneal clarity and function.
  • The impact of glaucoma treatments on corneal endothelium requires further characterization.

Purpose of the Study:

  • To quantify corneal endothelial morphology in glaucoma patients and controls.
  • To assess the effects of various glaucoma treatments on endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (Hex).

Main Methods:

  • A case-control study involving 304 eyes.
  • In vivo specular microscopy using a Konan NSP-9000.
  • Manual grading and CellChek software analysis of central corneal endothelium images.

Main Results:

  • Glaucomatous eyes exhibited significantly lower ECD than control and glaucoma suspect eyes.
  • Topical glaucoma drops, trabeculectomy, and tube shunt surgery were associated with reduced ECD.
  • Alpha agonists, carbonic anhydrase inhibitors (CAIs), and Rho-associated protein kinase (ROCK) inhibitors independently predicted significant ECD reduction, with ROCK inhibitors showing the greatest impact.

Conclusions:

  • Glaucoma treatments, including topical drops and surgical interventions, negatively affect corneal endothelial cell density.
  • Specific classes of glaucoma medications, particularly ROCK inhibitors, are associated with substantial endothelial cell loss.