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Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
Association between metabolic activity of visceral adipose tissue and retinal vein occlusion: a preliminary 18F-FDG
Kwang-Eon Choi1, Chanmin Joung2, Eungyu Yoon1
1Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.
Background:
Retinal vein occlusion (RVO) predominantly occurs in individuals over the age of 50, and obesity is a recognized risk factor for its development. The pro-inflammatory metabolic activity of visceral adipose tissue (VAT), which elevates systemic inflammation, is regarded as a key underlying mechanism contributing to the detrimental effects of obesity on atherosclerosis and hypercoagulability in RVO. In this study, we aimed to evaluate the inflammatory metabolic activity of VAT using 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and to examine its association with RVO.
Material And Methods:
A total of 22 elderly patients with RVO (aged ≥ 50 years) who underwent 18F-FDG PET/CT for routine health screening, along with 15 age-matched control participants who also underwent 18F-FDG PET/CT for routine health screening, were enrolled. The metabolic activity of VAT was assessed using its maximum standardized uptake value (SUVmax), while systemic inflammation was evaluated based on the SUVmax of the spleen and bone marrow (BM), as well as C-reactive protein (CRP) levels.
Results:
The VAT SUVmax was higher in patients with RVO compared to the non-RVO group. Additionally, levels of systemic inflammation surrogate markers were elevated in patients with RVO relative to those without RVO. Furthermore, VAT SUVmax showed a positive correlation with systemic inflammation surrogate markers and was independently associated with the presence of RVO.
Conclusions:
The metabolic activity of VAT, as assessed by 18F-FDG PET/CT, was found to be associated with the presence of RVO and correlated with the degree of systemic inflammation. Therefore, VAT SUVmax may serve as a potential surrogate marker for obesity-related VAT inflammation linked to RVO.
