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Hypertensive Response During Dobutamine Stress Echocardiography: Does it Indicate a Higher Risk of Developing
Hedieh Alimi1, Amirhossein Mirzaei2, Maryam Soleimani Farzaghi2
1Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
Abnormal blood pressure responses during dobutamine stress echocardiography (DSE) do not predict future cardiovascular events. This study found no significant differences in adverse outcomes between patients with and without hypertensive responses during DSE.
Area of Science:
- Cardiology
- Clinical Medicine
- Diagnostic Imaging
Background:
- Abnormal blood pressure (BP) responses are a common complication of dobutamine stress echocardiography (DSE).
- Understanding the implications of these BP responses is crucial for patient management.
Purpose of the Study:
- To investigate the relationship between hypertensive responses during DSE and subsequent cardiovascular outcomes.
- To determine if abnormal BP responses during DSE are predictive of adverse events.
Main Methods:
- A cohort study comparing patients with (n=62) and without (n=55) hypertensive responses during DSE.
- Exclusion criteria included prior hypertension and diabetes.
- Follow-up for 4 years monitored for hypertension, myocardial infarction (MI), heart disease hospitalization, death, and stroke.
Main Results:
- Patients with hypertensive responses during DSE had higher baseline systolic and diastolic BP and received higher dobutamine doses.
- No statistically significant differences were found between groups in rates of death, acute MI, chronic hypertension, diabetes, or hospitalization.
- Baseline BP and dobutamine dosage were significantly higher in the hypertensive response group.
Conclusions:
- Hypertensive responses during DSE are not associated with increased adverse cardiovascular outcomes in patients without prior hypertension or diabetes.
- Larger sample sizes may be needed to detect subtle differences in hypertension rates.
- The findings suggest that abnormal BP responses during DSE may not be a significant predictor of long-term cardiovascular risk in this population.
Background:
One of the most common complications associated with dobutamine stress echocardiography (DSE) is abnormal blood pressure (BP) responses.
Aims And Objectives:
The current investigation aimed to examine the blood pressure responses during DSE and its potential implications on cardiovascular outcomes.
Methods:
The study enrolled patients who lacked a history of hypertension and diabetes but demonstrated hypertensive response during DSE (n = 62). An equal number of patients who did not exhibit an increase in BP during the DSE were selected as the control group (n = 55). Throughout the 4-year clinical follow-up, we monitored the incidence of hypertension, myocardial infarction (MI), hospitalization due to heart disease, death, and stroke.
Results:
Among those who demonstrated a hypertensive response during DSE, baseline systolic BP (P = 0.002) and diastolic BP (P = 0.002) were notably higher compared to the nonhypertensive group. In addition, the hypertensive group received a significantly elevated dosage of dobutamine in comparison to the controls (P = 0.010). However, no statistically significant variances were observed between the two groups concerning death (P = 0.600), acute MI (P > 0.999), chronic hypertension (P = 0.063), diabetes mellitus (P = 0.513), and hospitalization (P = 0.472).
Conclusion:
In light of our findings, hypertensive responses in patients undergoing DSE do not correlate with subsequent adverse outcomes. While our investigation did not identify a statistically significant difference in hypertension rates, it is essential to note that significance may be achieved with future research involving a larger sample size.
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