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Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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A Direct-to-Patient Digital Health Program for Lung Cancer Screening: A Randomized Clinical Trial.

David P Miller^1,2, Anna C Snavely³, Ajay Dharod^1,2

¹Department of Implementation Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

|October 20, 2025

Summary

This summary is machine-generated.

A digital health program significantly increased lung cancer screening rates among eligible individuals compared to usual care. This intervention shows promise for improving early detection of lung cancer.

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Area of Science:

Pulmonology
Digital Health
Public Health

Background:

Lung cancer screening via chest computed tomography (CT) reduces mortality in high-risk individuals.
Screening rates in the US remain low, with less than 20% of eligible individuals participating.
Effective strategies are needed to increase uptake of lung cancer screening.

Purpose of the Study:

To evaluate the effectiveness of a direct-to-patient digital health program in increasing lung cancer screening rates.
To compare screening completion rates between a digital health intervention and enhanced usual care.

Main Methods:

A randomized clinical trial enrolled 1333 eligible individuals aged 50-77 years.
Participants were randomized to either the mPATH-Lung digital health program or enhanced usual care.
The primary outcome was chest CT completion within 16 weeks.

Main Results:

Chest CT completion was significantly higher in the mPATH-Lung group (24.5%) compared to the control group (17.0%).
The odds ratio for CT completion in favor of the intervention was 1.6 (95% CI, 1.2-2.1).
False-positive results and invasive procedures were low and similar between groups.

Conclusions:

A direct-to-patient digital health intervention effectively increased lung cancer screening rates.
Digital health strategies hold potential for improving lung cancer screening program reach.
Further research is needed to assess effectiveness across diverse populations and settings.