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Do Anticoagulants Have an Impact on the Clinical Outcomes of Ventral Hernia Repair? A Systematic Review and

Caroline Daleaste Wilmsen1, Augusto Graziani E Sousa2, Raquel Nogueira3

  • 1Universidade do Planalto Catarinense, Lages, Brazil.

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
|October 20, 2025
PubMed

Insights

Anticoagulation therapy after ventral hernia repair (VHR) increases risks of bleeding complications and reoperations. However, transfusion rates were similar, and further research on minimally invasive surgery is needed.

Area of Science:

  • General Surgery
  • Surgical Outcomes
  • Pharmacology

Background:

  • Ventral hernia repair (VHR) is a common surgical procedure.
  • Anticoagulation (AC) therapy is often necessary for various medical conditions.
  • The impact of AC on VHR outcomes requires clarification.

Purpose of the Study:

  • To systematically review and meta-analyze the effect of AC therapy on clinical outcomes following VHR.
  • To assess risks of bleeding, reoperation, and other complications in patients on AC.

Main Methods:

  • Comprehensive search of PubMed, Cochrane, and Embase databases.
  • Inclusion of studies comparing AC therapy use post-VHR.
  • Analysis of bleeding-related reoperation, hemorrhagic/thrombotic complications, length of stay, and transfusion rates using random-effects model.

Main Results:

  • Analysis of 4 studies with 41,868 patients (4804 on AC).
  • Increased hemorrhagic/thrombotic complications (RR: 2.3) and bleeding-related reoperations (RR: 6.5) in AC group.
  • Prolonged hospital stays (1.69 days longer) observed in patients on AC therapy.

Conclusions:

  • AC therapy post-VHR is linked to higher rates of hemorrhagic/thrombotic complications and bleeding-related reoperations.
  • Hospitalization duration is extended for patients on AC therapy.
  • Transfusion rates did not significantly differ; further investigation into minimally invasive surgery (MIS) impact is warranted.
Abstract

Keywords:
anticoagulantsanticoagulationoutcomes assessmentventral hernias

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