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Updated: Jan 14, 2026

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
Published on: September 5, 2019
Density-dependent transport coefficients in two-dimensional cellular aggregates
Subhadip Chakraborti1, Vasily Zaburdaev1
1Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Biology, 91058 Erlangen, Germany and Max Planck Zentrum für Physik und Medizin, 91054 Erlangen, Germany.
Abstract:
The large-scale collective behavior of biological systems can be characterized by macroscopic transport, which arises from the nonequilibrium microscopic interactions between individual constituents. A prominent example is the formation of dynamic aggregates by motile eukaryotic cells or bacteria mediated by active contractile forces. In this work we develop the two-dimensional fluctuating hydrodynamics theory based on the microscopic dynamics of a model system of aggregation by Neisseria gonorrhoeae bacteria. The derivation of two macroscopic transport coefficients of bulk diffusivity and conductivity which determine the hydrodynamic current of cells is the central result of this work. By showing how transport coefficients depend on cell density and microscopic parameters of the system, we predict transport slowdown during the colony formation process. This study provides valuable analytical tools for quantifying hydrodynamic transport in experimental systems involving cellular aggregation occurring due to intermittent contractile dipole forces.
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