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Draft genome sequences of human adenovirus F associated with acute gastroenteritis in Blantyre, Malawi

Flywell Kawonga1,2,3, Ernest Matambo1,2,4, End Chinyama1,5

  • 1Malawi-Liverpool-Wellcome Programme, Queen Elizabeth Central Hospital, Blantyre, Malawi.

Microbiology Resource Announcements
|October 21, 2025
PubMed

Insights

Human adenovirus F (HAdV-F) genotype 40/41 causes significant pediatric viral gastroenteritis. This study presents four new HAdV-F genomes from Malawian children, contributing to global health data.

Area of Science:

  • Virology
  • Genomics
  • Pediatric Gastroenterology

Background:

  • Human adenovirus F (HAdV-F), specifically genotype 40/41, is a major global cause of viral gastroenteritis in children.
  • Understanding the genetic diversity of HAdV-F is crucial for developing effective public health interventions.

Purpose of the Study:

  • To report the draft genome sequences of HAdV-F genotype 40/41 identified in children with acute gastroenteritis in Malawi.
  • To contribute genomic data of HAdV-F from a previously underrepresented region.

Main Methods:

  • Collection of samples from pediatric patients diagnosed with acute gastroenteritis.
  • Whole-genome sequencing to obtain draft genome sequences of HAdV-F.
  • Bioinformatic analysis of the generated viral genomes.

Main Results:

  • Four draft genome sequences of Human adenovirus F (HAdV-F) genotype 40/41 were successfully obtained.
  • The genomes were derived from samples collected between 2012 and 2024 in Blantyre, Malawi.

Conclusions:

  • This study provides novel genomic data for HAdV-F genotype 40/41 from Malawi.
  • The findings enhance the understanding of HAdV-F epidemiology and genetic diversity in sub-Saharan Africa.
Keywords:
MalawiSACEVadenovirus genomicsenteric virusesgenotype 40/41human adenovirus F (HAdV-F)pediatric gastroenteritisphylogeneticswhole-genome sequencing

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