Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioremediation00:46

Bioremediation

17.4K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
17.4K
Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

200
Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
200

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiation-induced neurotoxicity: investigating human neuronal damage in MEA-integrated microfluidic platforms.

RSC advances·2026
Same author

Seaweed Derived Polysaccharides as Sustainable Biomaterials for Tissue Engineering Applications.

ACS biomaterials science & engineering·2025
Same author

Development of in vitro cardiovascular tissue models within capillary circuit microfluidic devices fabricated with 3D stereolithography printing.

SN applied sciences·2025
Same author

Highly Sensitive Graphene-Assisted Large-Area Kapton-Based Flexible Surface Plasmon Resonance Biosensor for Enzymatic Glucose Detection.

ACS applied materials & interfaces·2025
Same author

Low-Temperature Deposition of Gold Patterns with Improved Adhesion and Conductivity Characteristics for Printed Electronic Applications.

ACS applied materials & interfaces·2025
Same author

Adoption of microfluidic MEA technology for electrophysiology of 3D neuronal networks exposed to suborbital conditions.

NPJ microgravity·2025

Related Experiment Video

Updated: May 4, 2026

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications
05:20

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Published on: May 31, 2018

15.2K

Development and optimization of decellularized seaweed scaffolds for tissue engineering.

Gobinath Chithiravelu1,2, Marion J Jones1,2, Ivana Hernandez de Estrada1,2

  • 1Inspired Materials and Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Oregon State University, 105 SW 26th St., Corvallis, Oregon 97331.

Biointerphases
|October 21, 2025
PubMed
Summary

Pacific dulse, a seaweed, offers a sustainable, animal-free tissue scaffold for growing human heart cells. This green biomaterial shows excellent biocompatibility and cell growth for tissue engineering applications.

More Related Videos

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.6K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

455

Related Experiment Videos

Last Updated: May 4, 2026

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications
05:20

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Published on: May 31, 2018

15.2K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.6K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

455

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Marine Biotechnology

Background:

  • Traditional tissue scaffolds often rely on animal-derived materials, raising ethical and contamination concerns.
  • Developing sustainable, biocompatible, and animal-free alternatives is crucial for advancing regenerative medicine.
  • Marine organisms, like seaweed, present unique extracellular matrix properties suitable for biomaterial development.

Purpose of the Study:

  • To investigate the red seaweed *Devaleraea mollis* (Pacific dulse) as a novel, sustainable, animal-free tissue scaffold.
  • To develop and characterize cellulose-based scaffolds derived from Pacific dulse for supporting human cardiomyocyte growth.
  • To evaluate the biocompatibility and cell proliferation capabilities of these seaweed-derived scaffolds.

Main Methods:

  • Decellularization of native dulse using varying concentrations of sodium dodecyl sulfate (SDS), Triton X-100, and NaClO.
  • Comprehensive characterization of scaffold architecture and composition using light microscopy, SEM, FTIR, and Raman spectroscopy.
  • In vitro assessment of scaffold biocompatibility, biodegradation, and human cardiomyocyte attachment, viability, and proliferation.

Main Results:

  • Scaffolds processed with 10-15% SDS demonstrated superior structural integrity and preserved cellulose content.
  • Seaweed-derived scaffolds exhibited excellent biocompatibility with human cardiomyocytes.
  • High cell viability, proliferation (2.5x normalized), and significant surface coverage (90% by day 6) were observed.

Conclusions:

  • Seaweed-derived cellulose, specifically from *Devaleraea mollis*, is a highly promising biomaterial for tissue engineering.
  • These scaffolds offer a sustainable, biocompatible, and animal-free alternative for cardiac cell culture and regenerative medicine.
  • This research opens new avenues for innovative biomedical applications using eco-friendly marine resources.