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Seaweed Derived Polysaccharides as Sustainable Biomaterials for Tissue Engineering Applications.

Pradnya Ghalsasi1,2, Gobinath Chithiravelu1,2, Binata Joddar1,2

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ACS Biomaterials Science & Engineering
|October 15, 2025
PubMed
Summary

Seaweed polysaccharides offer versatile, bioactive biomaterials for tissue engineering scaffolds. Their sustainable and cost-effective nature, combined with advanced fabrication, advances regenerative medicine applications.

Keywords:
agarosealginatesbiofabricationbioprintingcarrageenanelectrospinningextracellular matrixhydrogelregenerative medicineseaweed-derived polysaccharidesstimuli-responsive materials

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Marine Biotechnology

Background:

  • Marine-derived polysaccharides from seaweed, including alginate and fucoidan, are abundant natural resources.
  • These polysaccharides offer unique structural and functional properties for tissue regeneration.
  • They possess inherent bioactivity, such as antioxidant effects and cell signaling capabilities.

Purpose of the Study:

  • To review recent advancements in seaweed-derived polysaccharide scaffolds for tissue engineering.
  • To highlight the potential of these biomaterials in soft and hard tissue regeneration.
  • To discuss fabrication techniques and inherent properties relevant to regenerative applications.

Main Methods:

  • Review of current literature on seaweed polysaccharides in tissue engineering.
  • Analysis of fabrication methods like 3D printing, electrospinning, and hydrogel casting.
  • Evaluation of inherent bioactivity and modification strategies for tailored applications.

Main Results:

  • Seaweed polysaccharides provide a sustainable and cost-effective alternative to synthetic biomaterials.
  • Their properties can be modified for specific tissue engineering requirements.
  • Various fabrication techniques enhance scaffold functionality for tissue regeneration.

Conclusions:

  • Seaweed-derived polysaccharides are promising biomaterials for advanced tissue engineering scaffolds.
  • Further research into biological mechanisms and scalable fabrication is crucial for clinical translation.
  • These natural materials support both soft and hard tissue regeneration effectively.