Physical activity and quality of life in statin users

Dyslipidemia is a major risk factor for cardiovascular disease, with statins widely prescribed to manage lipid levels. However, statin-associated muscle symptoms and the interplay with physical activity (PA) may impact patients' quality of life (QoL). This study aimed to explore the relationship between PA levels and QoL in statin users.

A cross-sectional study was conducted among 384 adult statin users attending Dokuz Eylül University Family Health Centers. PA was assessed using the International Physical Activity Questionnaire, and QoL was evaluated with the Short Form-36 Health Survey. Due to the non-normal data distribution, nonparametric statistical tests were applied.

Of the participants, 18.2% were inactive, 65.1% minimally active, and 16.7% very active. Higher PA levels were associated with significantly better scores in physical functioning, role limitations due to physical health, energy/fatigue, social functioning, pain, and general health (P < 0.001). Sitting duration was negatively correlated with most Short Form-36 domains. No significant association was found between PA and role limitations due to emotional problems.

Higher physical activity levels are positively associated with better quality of life among statin users, despite potential concerns regarding muscle symptoms. Regular, moderate physical activity may enhance this population's physical and mental health outcomes.