The rhizomatic parasite-host interactions in the holobiont era

Area of Science:

• Parasitology
• Ecology
• Systems Biology

Background:

• Postgenomic research in parasitology has often focused on reductionist approaches.
• Complex diseases like Chagas disease require more holistic research frameworks.
• Current approaches may not adequately address the intricate interactions within disease systems.

Purpose of the Study:

• To propose a novel theoretical framework for studying complex parasitic diseases.
• To advocate for an ecologically grounded approach in parasitology.
• To integrate social and biological dimensions in disease research.

Main Methods:

• Conceptual analysis and theoretical framework development.
• Literature review of postgenomic parasitology and systems ecology.
• Application of rhizomatic philosophy to parasite-host-microbiota interactions.

Main Results:

• Identified limitations of digital reductionism in postgenomic parasitology.
• Proposed a rhizomatic framework viewing parasite-host-microbiota as an interconnected ecosystem.
• Highlighted the need for integrating social and biological realities for a comprehensive understanding.

Conclusions:

• A rhizomatic, ecologically grounded approach offers a more effective framework for complex parasitic diseases.
• Integrating social and biological factors is crucial for advancing Chagas disease research.
• This framework moves beyond reductionism towards a more holistic understanding of disease ecosystems.