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Related Concept Videos

Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

148
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
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Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
232
Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

178
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
178
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

260
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
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Estimation of k and VD of Aminoglycosides01:20

Estimation of k and VD of Aminoglycosides

212
Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
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Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

166
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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DOSAGE: Dataset for Optimized Safe Antibiotic Guidelines and Estimates.

Ferdous Wahid Anik1, Marzia Zaman1,2, Tahmina Foyez3

  • 1Advanced Intelligent Multidisciplinary Systems (AIMS) Lab, Institute of Research Innovation, Incubation and Commercialization (IRIIC), United International University, Dhaka, 1212, Bangladesh.

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|October 21, 2025
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Summary

The DOSAGE dataset supports personalized medication dosing and pregnancy risk assessment using patient data. It was validated by experts to ensure clinical accuracy and workflow integration for better patient care.

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Area of Science:

  • Pharmacology and Clinical Pharmacy
  • Health Informatics

Background:

  • Personalized dosing is crucial for optimizing therapeutic outcomes and minimizing adverse drug reactions.
  • Existing clinical workflows often lack standardized tools for integrating patient-specific factors into medication management, especially concerning pregnancy risks.

Purpose of the Study:

  • To introduce the DOSAGE dataset, designed for personalized dosing regimens and pregnancy risk assessment.
  • To provide clinicians with a validated, standardized data resource for improved patient care.

Main Methods:

  • Development of a dataset covering 98 generic medications.
  • Validation through a multi-step process including manual review and expert corrections by healthcare professionals.
  • Rigorous assessment of data integrity, consistency, and clinical adherence via automated and manual checks.

Main Results:

  • A comprehensive dataset supporting personalized dosing based on age, weight, and renal function.
  • Validated data ensuring clinical adherence and consistency.
  • A tool designed for seamless integration into existing clinical workflows.

Conclusions:

  • The DOSAGE dataset offers a valuable resource for clinicians to enhance medication management.
  • Facilitates improved patient outcomes and quality of care through data-driven, personalized approaches.
  • Standardized data integration supports evidence-based clinical decision-making.