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Ferroptosis and non-coding RNAs in lung cancer: exploring molecular mechanisms and diagnostic/therapeutic
Hedong Xue1, Melika Malek2, Liangyu Li3,4
1Department of Respiratory, The First People's Hospital of Pinghu, Pinghu, 314200, Zhejiang, China.
Abstract:
Lung cancer is the second most prevalent type of cancer on a global scale, and is widely known for being the deadliest. Revealing the fundamental molecular mechanisms of this condition has the potential to unlock fresh possibilities and avenues for managing it. Ferroptosis is a newly discovered type of controlled cell death that distinguishes itself from traditional forms of programmed cell death, specifically apoptosis and necrosis, through its distinct biochemical and structural characteristics. Changes made to the mechanism that regulates ferroptosis can have a significant influence on the development of various illnesses, such as, though not limited to, lung cancer. Based on scientific studies, it has been proven that cancer cells possess a significant capability to inhibit ferroptosis, leading to their continuous growth and survival. The presence of non-coding RNAs has a profound influence on controlling a wide range of cellular functions, with a particular focus on cancer. They have been closely associated with all key features of lung cancer. Fresh findings have indicated that these particles also have the task of controlling ferroptosis. Thus, the use of non-coding RNA as a therapeutic strategy offers a potentially effective option for regulating ferroptosis in the management of cancer. The main focus of this overview is on ncRNAs and their function in controlling ferroptosis, specifically within the context of lung cancer.
Insights
Non-coding RNAs (ncRNAs) regulate ferroptosis, a cell death pathway crucial for controlling lung cancer. Targeting ncRNAs offers a novel therapeutic strategy for managing lung cancer by modulating ferroptosis.
Area of Science:
- Molecular Oncology
- Cell Death Mechanisms
- Cancer Therapeutics
Background:
- Lung cancer is a leading cause of cancer-related mortality globally.
- Ferroptosis, a distinct form of regulated cell death, plays a role in cancer development.
- Cancer cells often evade cell death pathways like ferroptosis to promote tumor growth.
Purpose of the Study:
- To review the role of non-coding RNAs (ncRNAs) in regulating ferroptosis.
- To explore the association between ncRNAs, ferroptosis, and lung cancer.
- To highlight ncRNAs as potential therapeutic targets for lung cancer management.
Main Methods:
- Literature review of studies on ncRNAs, ferroptosis, and lung cancer.
- Analysis of molecular mechanisms linking ncRNAs to ferroptosis regulation.
- Synthesis of current findings on ncRNA-mediated ferroptosis in lung cancer.
Main Results:
- ncRNAs are implicated in regulating diverse cellular functions, including cancer progression.
- Evidence suggests ncRNAs control ferroptosis, impacting lung cancer development.
- Cancer cells exhibit mechanisms to inhibit ferroptosis, contributing to their survival.
Conclusions:
- ncRNAs are key regulators of ferroptosis in the context of lung cancer.
- Modulating ncRNA function presents a promising therapeutic avenue for lung cancer treatment.
- Targeting ncRNA-mediated ferroptosis could offer novel strategies for lung cancer management.
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