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BEACON: An Artificial Intelligence-Powered Optimized Biobank Sample Management System Leveraging Real-World Data.

Armin Ahmadi1,2, Vineetha Menon2,3, Gregory H Grossman4

  • 1Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, Alabama, USA.

Biopreservation and Biobanking
|October 22, 2025
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Summary
This summary is machine-generated.

Biobanks can improve efficiency and trust using artificial intelligence (AI). The Biobank Ethical AI Compliance and Optimization Navigator (BEACON) enhances sample management and ethical governance for sustainable biobanking.

Keywords:
artificial intelligencebiobankingethics in AIexplainable AIretrieval-augmented generation (RAG)

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Area of Science:

  • Biomedical research
  • Biobanking
  • Artificial Intelligence

Background:

  • Biobanks face operational inefficiencies, underutilization of specimens, and ethical governance challenges.
  • Advancing biomedical research relies heavily on efficient and ethically managed biobanks.
  • Current biobanking practices often lack advanced technological solutions for optimization.

Purpose of the Study:

  • To introduce the Biobank Ethical AI Compliance and Optimization Navigator (BEACON) system.
  • To demonstrate AI's potential in enhancing biobank operational efficiency and ethical compliance.
  • To address challenges in specimen management and utilization within biobanks.

Main Methods:

  • Leveraging artificial intelligence (AI) for enhanced sample management and workflow optimization.
  • Integrating retrieval-augmented generation systems, embedding-based semantic search, and GPT-powered response generation.
  • Validating the system through real-world collaboration with the Advancing Sight Network.

Main Results:

  • BEACON demonstrated enhanced biobank workflows and improved operational efficiency.
  • The system provided precise and transparent specimen allocation through AI-driven decisions.
  • Validation fostered community trust via transparent and explainable AI functionalities.

Conclusions:

  • BEACON offers a transformative AI solution for operational inefficiencies in biobanking.
  • The system promotes equitable and sustainable biobanking operations globally.
  • BEACON's modular design ensures scalability and adaptability across diverse biobank infrastructures.