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Published on: September 20, 2018
[Clinical characteristics of Behçet syndrome in 45 children]
Chen-Xi Wei1, Shu-Feng Zhi, Li-Jun Jiang
1Department of Pediatrics, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Insights
Pediatric Behçet syndrome (BS) presents with diverse symptoms, including oral ulcers and gastrointestinal issues. HLA-B51 is linked to disease susceptibility in children.
Area of Science:
- Pediatric Rheumatology
- Immunology
- Gastroenterology
Objectives:
To study the clinical characteristics of pediatric Behçet syndrome (BS).
Methods:
A retrospective review was conducted on the medical records of children hospitalized in the Department of Pediatrics at the Second Hospital of Hebei Medical University between December 2014 and December 2024 who met diagnostic criteria for BS.
Results:
Among 45 children with BS, 26 (58%) were male. Oral aphthous ulcers were the most common manifestation (43/45, 96%), followed by genital ulcers (23/45, 51%) and gastrointestinal involvement (18/45, 40%). Genital ulcers were more frequent in girls, whereas ocular involvement was more common in boys (P<0.05). The pathergy test was positive in 10 (22%), and HLA-B51 was positive in 13 (29%). Fecal calprotectin (FC) was elevated in 16 (36%); gastrointestinal involvement was more frequent in children with elevated FC than in those with normal FC (P<0.05). According to the respective criteria, 17 (38%) patients met the International Study Group criteria (1990), 33 (73%) met the International Criteria for Behçet Disease (2014), and 13 (29%) met the Pediatric Behçet Disease criteria (2015).
Conclusions:
Pediatric BS shows marked clinical heterogeneity. HLA-B51 is associated with disease susceptibility.
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